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Research that has been conducted on mice has shown some validity in possibly using the drug for treating the symptoms of depression, however, the doctors do not believe that it can be used as an anti-depressant unless it is needed in such cases when the other depression meds that are given have failed.

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The overdose of Tramadol would lead to some risk factors that include depression, addiction to the drug, and seizures. The toxic effects caused by Tramadol overdose can be reversed just partially by Naloxone but it might increase the risk of seizures in the patient.
There are many death reports that have been recorded which were caused by the usage of Tramadol overdose and these are still increasing in Northern Ireland. From the report, the overdose has been mostly caused by the drug interaction of Tramadol with other drugs that include alcohol too. There are many other deaths that have been recorded within the United States and are mostly in Florida. It is better to take a consultation with a licensed physician before procuring Tramadol.

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The medication is known to work for two underlying functions. It binds with opioid receptors in the brain that stops the nerve from sending pain signals to the brain. It also helps to reduce the pain by increasing the effect of serotonin and noradrenaline.

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What is Tramadol used for?
The FDA approves the drug for the treatment of moderate to moderately severe chronic pain in adults such as back pain, fibromyalgia, and so on, which is the most well-known of the Tramadol uses. The drug itself has no activity on opioid receptors but instead works through the actions of one of its major metabolites O-desmethyl Tramadol. This activity at opioid receptors is the primary mechanism behind the analgesic properties of the medication. The parent drug also inhibits the reuptake of norepinephrine and serotonin, contributing to its analgesic properties.
Tramadol another use includes using it for relieving pain from back pain, sciatica, and for postoperative pain following spine surgery. For most adults, the maximum safe dose is 400 mg per day of immediate-release tablets. It has been proved that tramadol hydrochloride can allow a significant reduction in the dose of NSAID without compromising the relief of pain.

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